angry, upset
Ella está muy enfadada con sus hijos.
She is very angry with her children.
Estabas enfadada con él, no sé por qué vas a su fiesta.
You were angry with him, I don't know why you're going to his party.
— Nicky, la aprendiz de bruja (1989)
Sé que probablemente estés enfadada acerca de lo que dije ayer.
I know you’re probably upset about what I said yesterday.