annoys, bothers
Su esposa le fastidia constantemente.
His wife constantly annoys him.
Me fastidia no llegar a tiempo.
It annoys me not to arrive on time.
I hate going shopping.
Nadia, that's already annoying.
— La ironía del destino, o goce de su baño (1976)
Lo que me fastidia no es lo que dice sino la manera en que lo dice.
What bothers me isn’t what he says but the way he says it.