に手を出す

get involved in

→ に
phrase Uncommon #10,585
get involved in Used for getting involved in, meddling with, or dabbling in something, often with a negative implication that it is risky, inappropriate, or beyond one's area of expertise. With a person, it can mean to mess with or attack them.
JA: 初心者がいきなり株に手を出すのは危険だ。
EN: It’s dangerous for a beginner to start dabbling in stocks right away.

新しい物事に手を出すのを恐れるな

Don't be afraid to try new things.

警官に手を出すのか

You gonna hit a cop?

— エリート・スクワッド (2007)

に手を出すなんて彼女はなんと愚かなのだろう

How foolish of her to dabble in stocks.

に手を出す女は大嫌い

I hate women who hit on men.

— インディ・ジョーンズ/最後の聖戦 (1989)

彼はすぐに手を出す

He gets physical right away.

麻薬に手を出す気はない

I have no intention of getting involved with drugs.

— シティ・オブ・ゴッド (2002)

一度にあまりたくさんのことに手を出すどこから始めてよいかわからないものだ

When you try to take on too many things at once, you don't know where to start.

多くのことに手を出すものは完成するものが少ない

Those who take on too many things finish few of them.