彼の失敗は

his failure

→ 彼
phrase Rare #23,980
his failure は marks 彼の失敗 (his failure) as the topic of the sentence; the phrase is usually followed by more information.
JA: 彼の失敗は経験不足が原因だった。
EN: His failure was due to a lack of experience.

彼の失敗は私が絶対に予想しなかったことである。

His failure was something I never expected.

彼の失敗は大部分不注意のせいだった。

His failure was largely due to carelessness.

彼の失敗は私には何の関係もない。

His failure has nothing to do with me.

彼の失敗は無知のせいである。

His failure is due to ignorance.

彼の失敗は辞職という結果になった。

His failure resulted in his resignation.

実際彼の失敗は不注意のためであった。

In fact, his failure was due to carelessness.

彼の失敗は私にとって良い教訓になりました。

His failure taught me a valuable lesson.

彼の失敗は性格と関係がありそうだ。

His failure seems to be related to his personality.

彼の失敗は考えられない。

His failure is unthinkable.