serious illness
あなたは流感になりかけているか、もっと重い病気かもしれません。
You may be coming down with the flu, or you might have something more serious.
彼は私たちと一緒に食事になっていたが、突然重い病気にかかってしまった。
He was having a meal with us when he suddenly fell seriously ill.
They came down with a serious illness and died the following year.
— When Marnie Was There (2014)