setback, failure
でも、挫折するなよ！
But don’t give up!
病気で彼の旅行の計画は挫折した。
His travel plans were derailed by illness.
病気のために彼の希望はすべて挫折した。
Because of his illness, all his hopes were dashed.
資金不足のためわれわれの計画は挫折した。
Our plan fell through due to a lack of funds.
野球選手に挫折して
After giving up on becoming a professional baseball player
— フィールド・オブ・ドリームス (1989)
挫折したの？
Did you give up?
— 花様年華 (2000)