は知らないと思うよ

I don't think [someone] knows

→ は
phrase Rare #31,808
I don't think [someone] knows A conversational way to say that you think someone is unaware of something. The person or topic comes before は, and the information they probably do not know comes before 知らないと思うよ.
JA: その店がもう閉まっていること、彼は知らないと思うよ。
EN: I don't think he knows that the store is already closed.

トムメアリーベジタリアンだとは知らないと思うよ

I don't think Tom knows that Mary is a vegetarian.

メアリーやったってことトムは知らないと思うよ

I don't think Tom knows that Mary did it.

僕らがここにいるってトムは知らないと思うよ

I don't think Tom knows we're here.

メアリーボストンからいつ戻ったのかトムは知らないと思うよ

I don't think Tom knows when Mary got back from Boston.

メアリー入院してることトムは知らないと思うよ

I don't think Tom knows that Mary is in the hospital.

僕がメアリー兄弟だってことトムは知らないと思うよ

I don't think Tom knows that I'm Mary's brother.