a hard blow
Beh, penso che sia stato un duro colpo per te.
Well, I think it was a heavy blow for you.
— Oppenheimer (2023)
L'epidemia di coronavirus sta causando un duro colpo al settore aereo.
The coronavirus epidemic is dealing a severe blow to the aviation industry.
"È stato un duro colpo, volevo andare a studiare a Londra."
It was a huge blow; I wanted to go study in London.
— Audition (2000)