disadvantage, drawback
Ne pas être grand n'est pas un désavantage.
Being short is not a disadvantage.
Chaque désavantage a son avantage.
Every disadvantage has its advantage.
Pourriez-vous clarifier, monsieur le ministre, le désavantage dont vous parlez ?
Could you clarify, Minister, the disadvantage you’re referring to?
— Star Trek (2009)
Chaque avantage a son désavantage.
Every advantage has its disadvantage.