ほとんどの人は

most people

→ 殆ど
phrase Rare #40,574
most people ほとんどの人 means “most people,” and は marks the phrase as the topic of the sentence.
JA: ほとんどの人はそのニュースを知りません。
EN: Most people don't know that news.

ほとんどの人は私たちについて何も知らない

Most people don't know anything about us.

ほとんどの人は右利きです

Most people are right-handed.

ほとんどの人は逸見氏が関西出身だとは知らない

Most people don't know that Mr. Henmi is from Kansai.

ほとんどの人はその計画について知らない

Most people don't know about the plan.