all his/her efforts
Parece que ella dedica todos sus esfuerzos a su carrera.
It seems that she dedicates all her efforts to her career.
A pesar de todos sus esfuerzos, reprobó el examen.
Despite all his efforts, he failed the exam.
Todos sus esfuerzos eran en vano.
All his efforts were in vain.
A pesar de haber dado todos sus esfuerzos, él reprobó el examen.
Despite giving it his all, he failed the exam.
Todos sus esfuerzos se han ido a la basura.
All their efforts have gone to waste.
— Bhaag Milkha Bhaag (2013)