で最も高い建物

the tallest building in

→ で
phrase Rare #43,061
the tallest building in The particle で marks the place or group being compared. 最も高い means “tallest” or “highest,” and 建物 means “building.”
JA: この町で最も高い建物はあのホテルです。
EN: That hotel is the tallest building in this town.

これは私が今までにみたうちで最も高い建物だ。

This is the tallest building I’ve ever seen.

世界で最も高い建物は何でしょう?

What is the tallest building in the world?

この市で最も高い建物です。

It is the tallest building in this city.

ハーバー・ハウスはスペンサー港で最も高い建物のひとつだった。

Harbor House was one of the tallest buildings in Spencer Harbor.