all his/her efforts
Parece que ella dedica todos sus esfuerzos a su carrera.
It seems that she dedicates all her efforts to her career.
A pesar de todos sus esfuerzos, reprobó el examen.
Despite all his efforts, he failed the exam.
A pesar de haber dado todos sus esfuerzos, él reprobó el examen.
Despite giving it his all, he failed the exam.
Todos sus esfuerzos eran en vano.
All his efforts were in vain.
Todos sus esfuerzos se han ido a la basura.
All their efforts have gone to waste.
— Bhaag Milkha Bhaag (2013)