no sé qué le pasa

I don't know what's wrong with him/her

→ no
phrase Rare #44,378
I don't know what's wrong with him/her Used to express uncertainty about someone's behavior, condition, or situation. The pronoun can change: no sé qué les pasa means “I don't know what's wrong with them,” and no sé qué le pasó refers to what happened to him or her.
SP: No sé qué le pasa a Marta; está muy callada hoy.
EN: I don't know what's wrong with Marta; she's very quiet today.

Realmente no sé qué le pasa.

I really don't know what's wrong with him/her/it.

— Fellini, ocho y medio (1963)

Cada vez cocina peor, no sé qué le pasa últimamente.

She's cooking worse and worse, I don't know what's wrong with her lately.

No sé qué le pasa.

I don't know what's wrong with him/her/it.

— [REC] (2007)