in itself; oneself
Spero torni presto in sé, così continueremo a leggere Don Chisciotte insieme.
I hope he comes to his senses soon, so we can continue reading Don Quixote together.
— Il buco (2019)
Mary ha perso fiducia in sé.
Mary has lost self-confidence.
Non è molto in sé oggi.
It's not much in itself today.
— Psyco (1960)