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虫の居所が悪い

to be in a bad mood

→ 虫
phrase Rare #37,263
to be in a bad mood An idiomatic expression meaning to be irritable or grumpy. Literally, it refers to a bug being in an uncomfortable location.
JA: 今日は虫の居所が悪いから、そっとしておいて。
EN: I'm in a bad mood today, so please leave me alone.

今日はトム、虫の居所が悪いのよ。

Tom's in a bad mood today.

虫の居所が悪いの？

Are you in a bad mood?

朝からメアリーの虫の居所が悪いんだけどさ、トム、何かした？

Mary’s been in a bad mood since this morning. Tom, did you do something?

私、今日、虫の居所が悪いの。

I'm in a bad mood today.