もうダメ

it's no good anymore

→ もう
phrase Uncommon #9,268
it's no good anymore Depending on context, it can mean something is spoiled or unusable, or that someone is exhausted or feels there is no hope.
JA: この牛乳、もうダメだ。
EN: This milk is no good anymore.

もうダメ…

I can't go on anymore…

— フィフス・エレメント (1997)

もうダメだわ

I'm done for.

— ダーク・プレイス (2015)

ピアもうダメだわ

Pia, I can't do this anymore.

— きっと、うまくいく (2009)

もうダメ

It's hopeless.

— REC / レック (2007)

もうダメかと思ったぜ

I thought it was all over.

— ウエスタン (1968)

アヤちゃんもうダメかも

Aya, I don’t think I can go on much longer.

— Perfect Days (2023)

一時はもうダメかと思った

For a moment, I thought it was all over.

— さらば、わが愛/覇王別姫 (1993)

このチーズもうダメじゃない

Isn’t this cheese gone bad already?

— PERFECT BLUE (1998)

私は…もうダメ…

I... I can't do this anymore...

— ムーラン・ルージュ (2001)