に手を出すな

don't mess with

→ に
phrase Rare #27,108
don't mess with A blunt warning not to interfere with, touch, or provoke someone or something. Depending on context, it can also mean not to make a move on someone.
JA: あの犬に手を出すな。
EN: Don't mess with that dog.

息子に手を出すな

Don't lay a hand on my son.

— ブレット・トレイン (2022)

オレ達に手を出すな

Don't mess with us.

— ファイト・クラブ (1999)

父に手を出すな

Don't lay a hand on my father.

— イップ・マン 序章 (2008)

俺に手を出すなって言ったんだ

I told you not to mess with me.

— 罪人たち (2025)

タタリ神に手を出すな呪いをもらうぞ!

Don't mess with the Tatarigami, or you'll get cursed!

— もののけ姫 (1997)

オレ達に手を出すな!

Don’t mess with us!

— ファイト・クラブ (1999)