Yap.Town

no sé qué le pasa

I don't know what's wrong with him/her

→ no
phrase Rare #43,544
I don't know what's wrong with him/her “Le” can refer to him, her, or you (formal), depending on context.
SP: No sé qué le pasa a Marta; está muy callada hoy.
EN: I don't know what's wrong with Marta; she's very quiet today.

Realmente no sé qué le pasa.

I really don't know what's wrong with him/her/it.

— 8½ (1963)

Mire, doctora Roy, yo no sé qué le pasa, pero será mejor llamar al Dr. Fell.

Look, Dr. Roy, I don't know what's wrong with him, but we'd better call Dr. Fell.

— Durante la tormenta (2018)

Cada vez cocina peor, no sé qué le pasa últimamente.

She's cooking worse and worse, I don't know what's wrong with her lately.

No sé qué le pasa.

I don't know what's wrong with him/her/it.

— [REC] (2007)