彼の妹は

his younger sister

→ 彼
phrase Rare #32,043
his younger sister 彼の means “his,” 妹 means “younger sister,” and は marks the phrase as the topic of the sentence.
JA: 彼の妹は大学生です。
EN: His younger sister is a college student.

彼の妹は二人とも美人です

Both of his younger sisters are beautiful.

ジョンと言えば彼の妹はどうなったかな

Speaking of John, I wonder what happened to his sister.

彼の妹は流行を重視し過ぎる

His younger sister cares too much about fashion trends.

彼の妹はアメリカいきません

His younger sister isn't going to America.

彼の妹は人気のテレビタレントだよ

His younger sister is a popular TV personality.

彼の妹はとてもかわいい

His younger sister is so cute.