はどうにもならない

can't be helped; there's nothing that can be done

→ は
phrase Rare #36,524
can't be helped; there's nothing that can be done An idiomatic expression indicating that a situation cannot be fixed, changed, or resolved. The noun or situation before は is what cannot be helped.
JA: 彼の計画はどうにもならない。
EN: There is nothing that can be done about his plan.

トムはどうにもならない状態にいる

Tom is in a hopeless situation.

これらの問題は我々にはどうにもならない

There’s nothing we can do about these problems.

彼の計画はどうにもならない

His plan is hopeless.

君の馬鹿はどうにもならない

There's no helping your stupidity.