answer, reply, respond to, meet
少しは身にこたえるだろ
It must be taking at least a little out of you.
— 大人は判ってくれない (1959)
彼には寒さがとてもこたえる。
The cold really gets to him.
その仕事は彼の健康にかなりこたえるだろう。
That job will probably take quite a toll on his health.
僕には寒さがひどくこたえる。
The cold really gets to me.