どうすりゃいいんだ

what should I do?

→ どう
phrase Uncommon #13,376
what should I do? A casual, emphatic way to ask what to do, often expressing uncertainty or frustration. すりゃ is a contraction of すれば.
JA: こんな時、どうすりゃいいんだ?
EN: What should I do in a situation like this?

俺はどうすりゃいいんだ?

What am I supposed to do?

— ニュー・シネマ・パラダイス (1988)

百姓はどうすりゃいいんだよ

What are ordinary people supposed to do?

— 七人の侍 (1954)

俺はどうすりゃいいんだよ

What am I supposed to do?

— レザボア・ドッグス (1992)

一体百姓はどうすりゃいいんだ

What the hell are farmers supposed to do?

— 七人の侍 (1954)

どうすりゃいいんだ?

What am I supposed to do?

— ソング・オブ・ザ・シー 海のうた (2014)