to fuck; to screw; to be a pain in the assA very vulgar expression. In the pattern “que le/te/os den por el culo,” it is an insulting dismissal meaning “fuck him/her/them,” “fuck you,” or “screw them.”
SP: No quiero dar por el culo a nadie; solo estoy defendiendo mi decisión.
EN: I don't want to be a pain in anyone's ass; I'm just defending my decision.